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Tocris Bioscience™ ZE 132
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Product Code. 18787366
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Quantity:
2 mg
Unit Size:
2mg
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Product Code. 18787366 Supplier Tocris Bioscience™ Supplier No. 7533/2

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Description

Potent and selective PD-1/PD-L1 interaction inhibitor

ZE 132 binds to programmed cell death-ligand 1 (PD-L1) with high affinity (KD = 19.36 nM); it potently and selectively inhibits the interaction between programmed cell death-1 (PD-1) and PD-L1 (IC50 = 23.49 nM). ZE 132 promotes CD8+ T cell activation and improves the in vitro cytotoxic killing activity of T-cells. ZE 132 treatment can increase Cxcl9 mRNA expression and lower Tgfb1 mRNA expression in CT26 mouse colorectal cancer model. ZE 132 shows antitumor effects, inhibiting growth of CT26 tumors in mice by 64%.
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Specifications

Chemical Name or Material 2-[[[5-Chloro-2-[(5-cyano-3-pyridinyl)methoxy]-4-[[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy]phenyl]methyl][3-(dimethylamino)propyl]amino]ethanesulfonic acid
CAS 2566710-63-0
Quantity 2 mg
Target Additional Apoptosis-related Compounds
Molecular Formula C37H41ClN4O7S
Purity 0.98
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