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Invitrogen™ Zika Virus NS5 (strain H/PF/2013) Polyclonal Antibody
Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA5143441
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Beschreibung
Store as concentrated solution. Centrifuge briefly prior to opening vial. Positive control: Zika-infected Vero.
Zika Virus nonstructural protein 5 (NS5) interacts with the host retinoic acid-inducible gene I (RIG-I), which is an essential signaling molecule for defending pathogen infections. NS5 subsequently represses K63-linked polyubiquitination of RIG-I, attenuates the phosphorylation and nuclear translocation of interferon regulatory factor 3 (IRF3), and inhibits the expression and production of interferon-beta (IFN-beta), thus restricting the RIG-I signaling pathway.
Spezifikation
| Zika Virus NS5 (strain H/PF/2013) | |
| Polyclonal | |
| Unconjugated | |
| NS5; NS5 protein | |
| Recombinant protein encompassing a sequence within the N-terminus region of Zika virus NS5 protein (Zika virus (strain H/PF/2013)). The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunoprecipitation, Western Blot, Immunocytochemistry | |
| 0.78 mg/mL | |
| PBS with 20% glycerol and 0.025% Proclin 300; pH 7 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| Virus | |
| Antibody | |
| IgG |
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