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Invitrogen™ ZNF174 Polyclonal Antibody

Description
Immunogen sequence: VSGPQEALSQ LRQLCRQWLQ PELHTKEQIL ELLVMEQFLT ILPPEIQARV RHRCPMSSKE IVTLVEDFHR ASKKPKQWVA VCMQGQKVLL EKTGSQLGEQ ELPDFQPQTP RRDLRESSPA EPSQAGAYDR LSPHHWEKSP LLQ Highest antigen sequence indentity to the following orthologs: Mouse - 79%, Rat - 79%.
ZNF174, also known as ZSCAN8 or AW-1, is a transcriptional repressor that belongs to the Krueppel C2H2-type zinc-finger protein family. It is expressed in a number of different tissues, including small intestine, prostate, colon, spleen, pancreas, skeletal muscle, brain, heart, kidney and thymus, but it is most predominantly found in adult ovary and testis. ZNF174 specifically acts to repress the promoter activities of PDGF-B and TGF beta1. ZNF174 localizes to the nucleus and contains three C2H2-type zinc fingers at the C-terminus and one SCAN domain near the N-terminus. SCAN domains are found in a number of zinc-finger proteins and are characterized by a conserved region of 84 residues. The SCAN domain seemingly regulates the association of proteins containing SCAN domains into noncovalent complexes and may also function as an underlying mechanism in selective oligomerization of these proteins.
Specifications
Specifications
| Antigen | ZNF174 |
| Applications | Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry |
| Classification | Polyclonal |
| Concentration | 0.4 mg/mL |
| Conjugate | Unconjugated |
| Formulation | PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 |
| Gene | ZNF174 |
| Gene Accession No. | Q15697 |
| Gene Alias | AW1; AW-1; zinc finger and SCAN domain-containing protein 8; Zinc finger protein 174; ZNF174; ZSCAN8 |
| Gene Symbols | ZNF174 |
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