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Invitrogen™ ZNF638 Polyclonal Antibody

Rabbit Polyclonal Antibody

Brand:  Invitrogen™ PA557815

Product Code. 15715711

  • € 560.00 / 100µL

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Description

Description

Immunogen sequence: GLLKPTSARS GLAESSSKFK PTQSSLTRGG SGRISALQGK LSKLDYRDIT KQSQETEARP SIMKRDDSNN KTLAEQNTKN PK Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 76%.

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. NP220 (Nuclear protein 220), also designated Zinc finger protein 638 (ZNF638) or Cutaneous T-cell lymphoma-associated antigen se33-1, is a 1978 amino acid protein that contains one matrin-type zinc finger and two RRM (RNA recognition motif) domains, suggesting a role in transcriptional regulation. NP220 binds to double-stranded DNA fragments by recognizing clusters of cytidines. NP220 interacts with FHL-2 and is also thought to be phosphorylated by ATM or ATR upon DNA damage. It exists as five isoforms as a result of alternative splicing events. Isoform five of NP220 is a tumor-associated antigen found in several cutaneous T-cell lymphoma (CTCL), and in particular in mycosis fungoides patients and in Sezary syndrome patients.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ZNF638
Polyclonal
Unconjugated
ZNF638
AI323587; CTCL tumor antigen se33-1; CTCL-associated antigen se33-1; Cutaneous T-cell lymphoma-associated antigen se33-1; mNP220; Np220; NP220 nuclear protein; nuclear protein 220; Zfml; Zfp638; Zinc finger matrin-like protein; zinc finger protein 638; zinc finger, matrin-like; Znf638
Rabbit
Antigen affinity chromatography
RUO
27332
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Immunocytochemistry
0.2 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Q14966
ZNF638
Recombinant protein corresponding to Human ZNF638. Recombinant protein control fragment (Product #RP-95983).
100 μL
Primary
Human
Antibody
IgG
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