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Caveolin-1 (pY14) Mouse, Unlabeled, Clone: 56, BD
Mouse Monoclonal Antibody
Brand: BD Biosciences 611339
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Description
Caveolin (VIP21) localizes to non-clathrin membrane invaginations (caveolae) on the inner surface of the plasma membrane. In addition, it is present in the trans-Golgi network (TGN) and in apically and basolaterally destined transport vesicles. Caveolin is a transmembrane adaptor molecule that recognizes GPI-linked proteins and interacts with downstream cytoplasmic signaling molecules, such as src-family tyrosine kinases and hetero-trimeric G proteins. Caveolin forms large lipid-binding oligomers, which are thought to play a role in caveolae formation. It may also function as a scaffolding protein, which organizes signaling molecules. This functional role is supported by the fact that caveolin interacts directly with inactive ras and G-protein α subunits. Phosphorylation of caveolin at Tyr-14, Ser-88, and other residues in v-src transformed cells leads to flattening, aggregation, and fusion of caveolae and caveolae-derived vesicles. Thus, caveolin is the principle protein of caveolae and may be involved in v-src mediated cellular transformation.
Host Species: Mouse
Clone: 56
Isotype: IgG1
Species Reactivity: Human
Immunogen: Phosphorylated Human Caveolin-1 (Y14) Peptide
Formula Weight [Chemical]: 21-24kDa
Flow Cytometry, Immunofluorescence, Immunohistochemistry, Intracellular Staining, Western Blotting
Specifications
| Caveolin-1 (pY14) | |
| Monoclonal | |
| 250μg/mL | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Phosphorylated Human Caveolin-1 (Y14) Peptide | |
| 150 μg | |
| Cell Biology | |
| Human, Mouse, Rat | |
| IgG1 |
| Western Blot | |
| 56 | |
| Unconjugated | |
| Mouse | |
| Affinity Purified | |
| RUO | |
| Primary | |
| Store undiluted at -20°C. |
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