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Ezrin Mouse, Unlabeled, Clone: 18, BD
Mouse Monoclonal Antibody
€ 191.69 - € 329.03
Specifications
| Antigen | Ezrin |
|---|---|
| Clone | 18 |
| Concentration | 250μg/mL |
| Applications | Western Blot |
| Classification | Monoclonal |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
15825539
|
BD Biosciences
610602 |
50 μg |
 € 197.00 € 191.69 / 1 set Save € 5.31 2% Off |
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|
15835539
|
BD Biosciences
610603 |
150 μg |
€ 338.00 € 329.03 / 1 set Save € 8.97 2% Off |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
First described as an 80kDa protein concentrated in the apical cytoskeletal region of intestinal brush border cells, ezrin is now recognized as a major substrate of protein tyrosine kinases, such as the epidermal growth factor (EGF) tyrosine kinase. Ezrin is expressed at high levels in intestine, kidney, and placenta. In placenta, ezrin is present as monomers and non-covalent oligomers in tight association with actin microfilaments. In the human epidermoid carcinoma cell line A431, microvilli-like structures appear within 30 seconds after the addition of EGF. These structures give way to membrane ruffles after 2-5 minutes, followed by cell rounding after 10-20 minutes. At the same time, ezrin is recruited into these structures and oligomers are formed following its tyrosine phosphorylation. It is thought that tyrosine phosphorylation triggers the formation of ezrin oligomers.
Specifications
| Ezrin | |
| 250μg/mL | |
| Monoclonal | |
| Mouse | |
| Cell Biology | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| IgG1 | |
| Affinity Purified |
| 18 | |
| Western Blot | |
| Unconjugated | |
| RUO | |
| Canine, Human | |
| Aqueous buffered solution containing BSA, glycerol, and ≤0.09% sodium azide. | |
| Primary | |
| Store undiluted at -20°C. |
For Research Use Only.
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