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Invitrogen™ AVEN Recombinant Rabbit Monoclonal Antibody (24GB6865)
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA556989
This item is not returnable.
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Description
AVEN Recombinant Monoclonal Antibody for Western Blot
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.
Specifications
| AVEN | |
| Recombinant Monoclonal | |
| Unconjugated | |
| AVEN | |
| 1700013A01Rik; 1700056A21Rik; apoptosis and caspase activation inhibitor; apoptosis, caspase activation inhibitor; AVEN; Cell death regulator Aven; mAven-L; mAven-S; PDCD12; programmed cell death 12 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 311299, 57099, 74268 | |
| -20°C | |
| Liquid |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| 24GB6865 | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| Q9D9K3, Q9NQS1 | |
| AVEN | |
| A synthesized peptide derived from human AVEN (aa 113-126). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
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