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Tocris Bioscience™ AZ 628
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Product Code. 30001607
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30001607 50 mg 50mg
30001584 10 mg 10mg
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Product Code. 30001607 Supplier Tocris Bioscience™ Supplier No. 4836/50

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Description

Potent Raf kinase inhibitor

Potent, ATP-competitive inhibitor of Raf kinases (IC50 values are 29, 34 and 105 nM for c-Raf1, B-RafV600E and wild-type B-Raf, respectively). Displays selectivity for Raf kinases over a panel of 150 other kinases; inhibits activation of tyrosine protein kinases such as VEGFR2, Lyn, Flt1 and Fms. Also inhibits growth, and induces cell cycle arrest and apoptosis in colon and melanoma cell lines with the B-RafV600E mutation.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 878739-06-1
Molecular Formula C27H25N5O2

Specifications

Quantity 50 mg
Formula Weight 451.52
Purity >98%
Molecular Weight (g/mol) 451.53
Chemical Name or Material AZ 628
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