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CD19 Rat, anti-Mouse, Unconjugated, Clone: 1D3, STEMCELL Technologies
Rat Monoclonal Antibody
Brand: Stemcell Technologies 60112.1
This item is not returnable.
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Description
- The 1D3 antibody reacts with mouse CD19, an ∼95 kDa type 1 transmembrane glycoprotein expressed on the surface of B cells throughout all stages of development, from early pre-B cells to plasma cells
- Expression is down-regulated but persists in terminally differentiated plasma cells
- CD19 is also found on follicular dendritic cells
- By associating with CD21 and CD81, CD19 functions as a co-receptor for the B cell receptor and is involved in B cell activation and differentiation
- Activation of CD19 is accompanied by phosphorylation of the cytoplasmic domain, which promotes binding to kinases and the induction of intracellular signaling cascades
- Mutations in CD19 can result in severe immunodeficiency syndromes
- Clone 1D3 recognizes the same epitope as clone 6D5 in cross-competition assays
Specifications
| CD19 | |
| Monoclonal | |
| Unconjugated | |
| 100 μg | |
| Mouse | |
| B Cells |
| Immunohistochemistry, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Functional Assay | |
| 1D3 | |
| Rat | |
| Primary | |
| IgG2a κ |
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