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Tocris Bioscience™ GDC 0879
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Product Code. 18024862
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 18024862

Brand: Tocris Bioscience™ 4453/10

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This item is not returnable. View return policy

Description

Potent B-Raf inhibitor

Potent and selective B-Raf inhibitor (IC50 = 0.13 nM against purified B-Raf V600E). Activity reduces phospho-ERK (pERK) levels (IC50 = 63 nM in the Malme-3M cell line). Inhibits the Raf/MEK/ERK signaling pathway in V600E B-Raf mutant cell lines. Does not activate apoptotic pathways in A375 or Colo205 cell lines. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 905281-76-7
Molecular Formula C19H18N4O2

Specifications

Quantity 10 mg
Formula Weight 334.37
Purity >98%
Molecular Weight (g/mol) 334.379
Chemical Name or Material GDC 0879
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