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Heptelidic Acid, MP Biomedicals™

Product Code. 15927305 Shop All MP Biomedicals Products
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Quantity:
0.25 mg
1 mg
Unit Size:
1mg
250µg
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Product Code. 15927305

Brand: MP Biomedicals 02183371.2

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This item is not returnable. View return policy

Description

Potent, selective, irreversible GAPDH inhibitor, as well as a DNA polymerase inhibitor. The koningic acid molecule, produced by fungi that consume sweet potatoes, has been shown to curb the excessive glucose consumption in tumors exhibiting the Warburg effect and leaving healthy cells alone.

  • Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a key enzyme in carbohydrate metabolism, reversibly catalyzes the conversion of GAP to 1,3-bisphosphoglycerate and NAD+
  • A sesquiterpene lactone produced by the fungus T. koningii that was shown to have antibiotic activity against anaerobic bacteria such as Bacteroides
  • It acts as an irreversible inhibitor of GAPDH that binds to the cysteine-149 residue at the active site of the enzyme (Ki = 1.6 μM)
  • Can selectively induce apoptosis in high-glycolytic cancer cells by inhibiting the generation of ATP in the glycolytic pathway
  • Heptelidic acid is also a selective and competitive inhibitor of mammalian DNA polymerases β and λ as well as terminal deoxynucleotidyl transferase in family X of DNA polymerases (Kis range from 5.2-9.5 μM)
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 57710-57-3
Molecular Formula C15H20O5
Synonym Koningic Acid

Specifications

Quantity 0.25 mg
Color White
Purity >95
Molecular Weight (g/mol) 280.3
Chemical Name or Material Heptelidic Acid
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