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Invitrogen™ JAK1 Recombinant Rabbit Monoclonal Antibody (23GB2245), Invitrogen™
Rabbit Recombinant Monoclonal Antibody
Brand: Invitrogen™ MA553252
This item is not returnable.
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Description
Janus kinase 1 (JAK1), is a protein tyrosine kinase that is involved in the interferon-alpha/beta and -gamma signal transduction pathways. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
Specifications
| JAK1 | |
| Recombinant Monoclonal | |
| 0.5 mg/mL | |
| PBS with 50% glycerol and 0.02% sodium azide; pH 7.4 | |
| P23458, P52332 | |
| JAK1 | |
| A synthesized peptide derived from human JAK1 (625-660AA). | |
| 100 μL | |
| Primary | |
| Human, Mouse, Rat | |
| Antibody | |
| IgG |
| Flow Cytometry, Western Blot, Immunocytochemistry | |
| 23GB2245 | |
| Unconjugated | |
| JAK1 | |
| AA960307; BAP004; C130039L05Rik; EC 2.7.10.2; Jak1; JAK-1; JAK1A; JAK1B; Janus kinase 1; Janus protein tyrosine kinase 1; JTK3; kinase Jak1; Tyrosine-protein kinase JAK1 | |
| Rabbit | |
| Affinity chromatography | |
| RUO | |
| 16451, 3716, 84598 | |
| -20°C | |
| Liquid |
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