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Lomibuvir, MedChemExpress

Product Code. 16488198
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Product Code. 16488198 Supplier Medchem Express Supplier No. HY75800

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Description

MedChemExpress Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis.

Lomibuvir (VX-222), a selective, non-nucleoside polymerase inhibitor, targets thumb pocket 2 of the HCV NS5B polymerase (RdRp) with a Kd of 17 nM. Lomibuvir inhibits the 1b/Con1 HCV subgenomic replicon with an EC50 of 5.2 nM. Lomibuvir preferentially inhibits elongative RNA synthesis rather than de novo-initiated RNA synthesis.

Specifications

Chemical Name or Material Lomibuvir
CAS 1026785-55-6
Color White
Purity Grade Notes Research
Molecular Formula C25H35NO4S
Quantity 10 mg
Synonym VX-222
Solubility Information DMSO : 100 mg/mL (224.41 mM; Need ultrasonic)
SMILES O=C(C1=C(N([C@@H]2CC[C@@H](O)CC2)C([C@H]3CC[C@H](C)CC3)=O)C=C(C#CC(C)(C)C)S1)O
Molecular Weight (g/mol) 445.61
Formula Weight 445.61
Percent Purity 98.97%
Grade Research
Physical Form Solid
For Use With (Application) COVID-19-anti-virus
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Research purposes only

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