Invitrogen™ LRRN1 Monoclonal Antibody (K16288_6D3), Invitrogen™

Description

Sequence of this protein is as follows: ECPQLCVCEI RPWFTPQSTY REATTVDCND LRLTRIPSNL SSDTQVLLLQ SNNIAKTVDE LQQLFNLTEL DFSQNNFTNI KEVGLANLTQ LTTLHLEENQ ITEMTDYCLQ DLSNLQELYI NHNQISTISA HAFAGLKNLL RLHLNSNKLK VIDSRWFDST PNLEILMIGE NPVIGILDMN FKPLANLRSL VLAGMYLTDI PGNALVGLDS LESLSFYDNK LVKVPQLALQ KVPNLKFLDL NKNPIHKIQE GDFKNMLRLK ELGINNMGEL VSVDRYALDN LPELTKLEAT NNPKLSYIHR LAFRSVPALE SLMLNNNALN AIYQKTVESL PNLREISIHS NPLRCDCVIH WINSNKTNIR FMEPLSMFCA MPPEYKGHQV KEVLIQDSSE QCLPMISHDS FPNRLNVDIG TTVFLDCRAM AEPEPEIYWV TPIGNKITVE TLSDKYKLSS EGTLEISNIQ IEDSGRYTCV AQNVQGADTR VATIKVNGTL LDGTQVLKIY VKQTESHSIL VSWKVNSNVM TSNLKWSSAT MKIDNPHITY TARVPVDVHE YNLTHLQPST DYEVCLTVSN IHQQTQKSCV NVTTKNAAFA VDISDQETST

Leucine-rich repeat neuronal 1 (LRRN1) is a gene located on chromosome 3q23, which encodes a transmembrane protein belonging to the leucine-rich repeat (LRR) family. This protein plays a significant role in neural development and synaptic plasticity due to its involvement in cell-cell adhesion and signaling pathways. LRRN1 has been implicated in brain development processes, especially in synapse organization and neuronal differentiation. Its expression is primarily localized to the central nervous system, indicating its importance in neurodevelopmental functions. Research has highlighted LRRN1's potential involvement in cognitive functions, and alterations in its expression have been associated with various neurological disorders. Additionally, LRRN1 is thought to contribute to the establishment of neuronal networks by modulating interactions between neurons through extracellular matrix components. Current studies are exploring its contributions to neuropathological conditions, providing insights into its relevance in brain health and disease.