Invitrogen™ PMEL Biosimilar Recombinant Monoclonal Antibody

Description

For reconstitution, add sterile, distilled water to achieve a final antibody concentration of 1 mg/mL. Gently shake to solubilize the protein completely. Do not vortex. Reconstituted products should be stored at -80 °. This antibody can also be cross referenced by the term Genentech anti-PMEL17.

The Premelanosome protein (PMEL) gene, also known as PMEL17, plays a critical role in the formation of pigment cells. It is located on chromosome 12 and codes for a protein critical for melanosome biogenesis, the organelles responsible for melanin production. PMEL forms amyloid fibrils, which serve as a scaffold for melanin deposition, thus influencing pigmentation. The structure includes several domains, particularly a repeat (RPT) domain that governs the formation of fibrillar sheets. Mutations in PMEL can lead to pigmentation disorders and have been associated with conditions such as pigmentary glaucoma. Additionally, its expression and functionality are crucial in various species and can influence pigmentation patterns. The gene's evolutionary history highlights unique functional domains that contribute to its role in pigment cell biology.