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Tocris Bioscience™ Ro 3306
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Product Code. 18074302
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Product Code. 18074302 Supplier Tocris Bioscience™ Supplier No. 4181/10

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Description

Cdk1 inhibitor

Ro 3306 is an ATP-competitive cyclin-dependent kinase 1 (cdk1) inhibitor (Ki values range from 35 to 240 nM depending on cdk1 binding partner). Also reported to inhibit other cdks (Ki values are 0.89-1.32, 0.03 and >2 μM for cdk2, cdk3 and cdk4, respectively). Induces G2/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). RO 3306 also improves homology-directed repair (HDR) -mediated gene editing in hematopoietic stem and progenitor cells.
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Chemical Identifiers

CAS 872573-93-8
Molecular Formula C18H13N3OS2

Specifications

Quantity 10 mg
Formula Weight 351.45
Purity >98%
Molecular Weight (g/mol) 351.442
Chemical Name or Material Ro 3306
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