Invitrogen™ S-arrestin Monoclonal Antibody (S128)

Description

S-arrestin Monoclonal Antibody for Western Blot, ICC/IF, IHC

S-arrestin, also known as retinal arrestin or visual arrestin, is part of a small gene family that includes four members. It primarily functions in the retina, specifically within rod and cone photoreceptors. S-arrestin plays a crucial role in phototransduction by participating in the inactivation of opsin, which is a key component in the visual signaling pathway. Upon light stimulation, activated opsin interacts with a G-protein-coupled receptor kinase (GRK), leading to its phosphorylation. S-arrestin then binds to phosphorylated opsin to terminate the G-protein signaling, hence contributing to the process of vision adaptation and regulation of neurotransmitter release at the photoreceptor-bipolar cell synapse. This interaction is vital for the proper functioning of the visual cycle, ensuring that 11-cis-retinal is regenerated through the retinoid cycle. Mutations in the S-arrestin gene, like other rhodopsin alleles, are linked to various retinal disorders. The gene's expression pattern is specific to the retina, underscoring its role in vision, and it is distinct from other members of the arrestin family like beta-arrestins which regulate G-protein-coupled receptors (GPCRs) outside of the retina.