CAS RN 873837-23-1

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BMS-599626 Hydrochloride, MedChemExpress

MedChemExpress BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ∼8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy.

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Specifications

Molecular Weight (g/mol)	567.01
Color	White
Physical Form	Solid
Chemical Name or Material	BMS-599626 Hydrochloride
Grade	Research
SMILES	O=C(OC[C@H]1NCCOC1)NC2=CN(C3=C2C)N=CN=C3NC4=CC5=C(C=C4)N(CC6=CC(F)=CC=C6)N=C5.Cl
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.87%
CAS	873837-23-1
Solubility Information	DMSO : 100 mg/mL (176.36 mM; Need ultrasonic)
Health Hazard 1	H315∣H317∣H318∣H334∣H335∣H341∣H361∣H370∣H413
Synonym	AC480 Hydrochloride
Purity Grade Notes	Research
Recommended Storage	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Shelf Life	4°C, sealed storage, away from moisture∣In solvent : -80°C, 6 months∣-20°C, 1 month (sealed storage, away from moisture)
Molecular Formula	C₂₇H₂₈ClFN₈O₃
Formula Weight	567.01

CAS RN 873837-23-1

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