Pyrimidines And Derivatives

Aromatic organic compounds that consist of an aromatic six-membered ring containing two non-adjacent nitrogen atoms and four carbon atoms; includes compounds derived from pyrimidines.

1 – 15 of 92 results

LDN-212854, MedChemExpress

MedChemExpress LDN-212854 is a bone morphogenetic protein (BMP) inhibitor that potently inhibits ALK2 (IC50: 1.3 nM). LDN-212854 also inhibits ALK1 (IC50: 2.40 nM). LDN-212854 can be used in the research of fibrodysplasia ossificans progressive and cancers, such as hepatocellular carcinoma (HCC).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	406.48
Color	Light Yellow
Physical Form	Solid
Chemical Name or Material	LDN-212854
Grade	Research
SMILES	C12=C(C3=C4N=CC(C5=CC=C(N6CCNCC6)C=C5)=CN4N=C3)C=CC=C1N=CC=C2
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.65%
CAS	1432597-26-6
Solubility Information	DMSO : ≥ 30 mg/mL (73.80 mM)
Health Hazard 1	H301
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₂₂N₆
Formula Weight	406.48

Citarinostat, MedChemExpress

MedChemExpress Citarinostat (ACY241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with an IC50 of 2.6 nM (IC50s of 35 nM, 45 nM, 46 nM and 137 nM for HDAC1, HDAC2, HDAC3 and HDAC8, respectively). Citarinostat has anticancer effects.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	467.95
Color	White
Physical Form	Solid
Chemical Name or Material	Citarinostat
Grade	Research
SMILES	O=C(C1=CN=C(N(C2=CC=CC=C2Cl)C3=CC=CC=C3)N=C1)NCCCCCCC(NO)=O
For Use With (Application)	Cancer-programmed cell death
Percent Purity	95.0%
CAS	1316215-12-9
Solubility Information	DMSO : ≥ 30 mg/mL (64.11 mM)
Synonym	ACY241
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₂₆ClN₅O₃
Formula Weight	467.95

ABT-046, MedChemExpress

MedChemExpress ABT-046 is a potent, selective, and orally efficacious acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50= 8 nM).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	350.41
Color	Off-White
Physical Form	Solid
Chemical Name or Material	ABT-046
Grade	Research
SMILES	NC1=C(C2=CC=C([C@H]3CC[C@H](CC(O)=O)CC3)C=C2)C=NC4=CC=NN41
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	98.13%
CAS	1031336-60-3
Solubility Information	DMSO : 66.67 mg/mL (190.26 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₀H₂₂N₄O₂
Formula Weight	350.41

CZ415, MedChemExpress

MedChemExpress CZ415 is a potent and highly selective mTOR inhibitor with a pIC50 of 8.07. CZ415 inhibits mTORC1 and mTORC2 protein complex.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	459.56
Color	Off-White
Physical Form	Solid
Chemical Name or Material	CZ415
Grade	Research
SMILES	O=C(NCC)NC(C=C1)=CC=C1C2=NC3=C(CS(C3(C)C)(=O)=O)C(N4[C@@H](C)COCC4)=N2
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.74%
CAS	1429639-50-8
Solubility Information	DMSO : 100 mg/mL (217.60 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₂H₂₉N₅O₄S
Formula Weight	459.56

BMS-833923, MedChemExpress

MedChemExpress BMS-833923 (XL-139) is an orally bioavailable small-molecule inhibitor of Smoothened with potential antineoplastic activity; inhibits BODIPY cyclopamine binding to SMO in a dose-dependent manner with an IC50 of 21 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	473.57
Color	Yellow
Physical Form	Solid
Chemical Name or Material	BMS-833923
Grade	Research
SMILES	O=C(NC1=CC(CNC)=CC=C1C)C2=CC=C(NC3=NC(C4=CC=CC=C4)=C5C=CC=CC5=N3)C=C2
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.21%
CAS	1059734-66-5
Solubility Information	DMSO : 50 mg/mL (105.58 mM; Need ultrasonic)
Health Hazard 1	H302
Synonym	XL-139
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₃₀H₂₇N₅O
Formula Weight	473.57

MK-8617, MedChemExpress

MedChemExpress MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	443.45
Color	White
Physical Form	Solid
Chemical Name or Material	MK-8617
Grade	Research
SMILES	O=C(C1=CN=C(C2=NN=CC=C2)N=C1O)NC(C3=CC=C(OC)C=C3)C4=CC=C(OC)C=C4
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	98.02%
CAS	1187990-87-9
Solubility Information	DMSO : 6 mg/mL (13.53 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₂₁N₅O₄
Formula Weight	443.45

LDC000067, MedChemExpress

MedChemExpress LDC000067 is a highly specific CDK9 inhibitor with an IC50 value of 44±10 nM in vitro.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	370.43
Color	Off-White
Physical Form	Solid
Chemical Name or Material	LDC000067
Grade	Research
SMILES	O=S(CC1=CC=CC(NC2=NC=NC(C3=CC=CC=C3OC)=C2)=C1)(N)=O
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.58%
CAS	1073485-20-7
Solubility Information	DMSO : ≥ 47 mg/mL (126.88 mM)
Synonym	LDC067
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₁₈N₄O₃S
Formula Weight	370.43

BML-284, MedChemExpress

MedChemExpress BML-284 is a potent and cell-permeable Wnt signaling activator. BML-284 induces TCF-dependent transcriptional activity with an EC50 of 700 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	350.37
Color	White
Physical Form	Powder
Chemical Name or Material	BML-284
Grade	Research
SMILES	NC1=NC(C2=CC=CC(OC)=C2)=CC(NCC3=CC=C(OCO4)C4=C3)=N1
For Use With (Application)	Cancer-programmed cell death
Percent Purity	97.48%
CAS	853220-52-7
Solubility Information	DMSO : ≥ 100 mg/mL (285.41 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₉H₁₈N₄O₃
Formula Weight	350.37

Filorexant, MedChemExpress

MedChemExpress Filorexant (MK-6096) is an orally bioavailable potent and selective reversible antagonist of OX1 and OX2 receptor(<3 nM in binding).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	420.48
Color	Light Brown
Physical Form	Powder
Chemical Name or Material	Filorexant
Grade	Research
SMILES	CC1=CC(C(N2C[C@H](COC3=CC=C(F)C=N3)CC[C@H]2C)=O)=C(C4=NC=CC=N4)C=C1
For Use With (Application)	Neuroscience-Neuromodulation
Percent Purity	98.95%
CAS	1088991-73-4
Solubility Information	DMSO : 100 mg/mL (237.82 mM; Need ultrasonic)
Synonym	MK-6096
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₂₅FN₄O₂
Formula Weight	420.48

GDC-0349, MedChemExpress

MedChemExpress GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	452.55
Color	Yellow
Physical Form	Solid
Chemical Name or Material	GDC-0349
Grade	Research
SMILES	O=C(NCC)NC(C=C1)=CC=C1C2=NC3=C(CCN(C4COC4)C3)C(N5[C@@H](C)COCC5)=N2
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	95.0%
CAS	1207360-89-1
Solubility Information	DMSO : ≥ 100 mg/mL (220.97 mM)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₄H₃₂N₆O₃
Formula Weight	452.55

PF-4840154, MedChemExpress

MedChemExpress PF-4840154 is a potent, selective agonist of the rat and human TrpA1 channel with EC50s of 97 and 23 nM, respectively. PF-4840154 elicits TrpA1-mediated nocifensive behaviour in mouse.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	466.62
Color	Off-White
Physical Form	Solid
Chemical Name or Material	PF-4840154
Grade	Research
SMILES	O=C(C1=CN=C(N2CCN(CC3COCCC3)CC2)N=C1NCC(C)C)NCC4=CC=CC=C4
For Use With (Application)	COVID-19-immunoregulation
Percent Purity	99.0%
CAS	1332708-14-1
Solubility Information	DMSO : 50 mg/mL (107.15 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₆H₃₈N₆O₂
Formula Weight	466.62

Pyrimethamine, MedChemExpress

MedChemExpress Pyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).

Pricing and Availability
Specifications

Molecular Weight (g/mol)	248.71
Color	White
Physical Form	Solid
Chemical Name or Material	Pyrimethamine
Grade	Research
SMILES	NC1=NC(N)=C(C2=CC=C(Cl)C=C2)C(CC)=N1
For Use With (Application)	COVID-19-anti-virus
Percent Purity	99.9%
CAS	58-14-0
Solubility Information	DMSO : 20 mg/mL (80.41 mM; Need ultrasonic)
Health Hazard 1	H302
Synonym	Pirimecidan Pirimetamin RP 4753
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₂H₁₃ClN₄
Formula Weight	248.71

KDM4D-IN-1, MedChemExpress

MedChemExpress KDM4D-IN-1 is a new histone lysine demethylase 4D (KDM4D) inhibitor with an IC50 value of 0.41±0.03 μM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	225.21
Color	Earth Yellow
Physical Form	Solid
Chemical Name or Material	KDM4D-IN-1
Grade	Research
SMILES	OC1=NC2=C(C#N)C(C)=NN2C3=C1C=CC=N3
For Use With (Application)	Cancer-programmed cell death
Percent Purity	99.91%
CAS	2098902-68-0
Solubility Information	DMSO : 7.14 mg/mL (31.70 mM; Need ultrasonic)
Health Hazard 1	H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₁H₇N₅O
Formula Weight	225.21

EPZ015666, MedChemExpress

MedChemExpress EPZ015666 (GSK3235025) is an orally available inhibitor of PRMT5 with an IC50 of 22 nM.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	383.44
Color	White
Physical Form	Solid
Chemical Name or Material	EPZ015666
Grade	Research
SMILES	O=C(NC[C@H](O)CN1CCC(C=CC=C2)=C2C1)C3=CC(NC4COC4)=NC=N3
For Use With (Application)	Cancer-programmed cell death
Percent Purity	98.96%
CAS	1616391-65-1
Solubility Information	DMSO : 100 mg/mL (260.80 mM; Need ultrasonic)
Synonym	GSK3235025
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₀H₂₅N₅O₃
Formula Weight	383.44

mTOR inhibitor-3, MedChemExpress

MedChemExpress mTOR inhibitor-3 is a remarkably selective mTOR inhibitor with a Ki of 1.5 nM. mTOR inhibitor-3 suppresses mTORC1 and mTORC2 in cellular and in vivo pharmacokinetic (PK)/pharmacodynamic (PD) experiments.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	474.56
Color	White
Physical Form	Solid
Chemical Name or Material	mTOR inhibitor-3
Grade	Research
SMILES	O=C(NC1=CC=C(C2=NC(N3[C@@H](C)COCC3)=C4C(CN(C5=NC=CC=N5)CC4)=N2)C=C1)NCC
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	98.58%
CAS	1207358-59-5
Solubility Information	DMSO : 50 mg/mL (105.36 mM; Need ultrasonic)
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₂₅H₃₀N₈O₂
Formula Weight	474.56

Pyrimidines And Derivatives

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