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CAS RN 877399-52-5

CH3ClFClONNNNHNH2

CAS RN 877399-52-5

IUPAC Name: 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
Synonyms: crizotinib
Molecular Weight (g/mol): 450.34
Molecular Formula: C21H22Cl2FN5O
InChi Key: KTEIFNKAUNYNJU-UHFFFAOYNA-N
SMILES: CC(OC1=C(N)N=CC(=C1)C1=CN(N=C1)C1CCNCC1)C1=C(Cl)C=CC(F)=C1Cl
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1

Thermo Scientific Chemicals Crizotinib

CAS: 877399-52-5 Molecular Formula: C21H22Cl2FN5O Molecular Weight (g/mol): 450.34 MDL Number: MFCD12407409 InChI Key: KTEIFNKAUNYNJU-UHFFFAOYNA-N IUPAC Name: 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine SMILES: CC(OC1=C(N)N=CC(=C1)C1=CN(N=C1)C1CCNCC1)C1=C(Cl)C=CC(F)=C1Cl

CAS 877399-52-5
Molecular Weight (g/mol) 450.34
MDL Number MFCD12407409
SMILES CC(OC1=C(N)N=CC(=C1)C1=CN(N=C1)C1CCNCC1)C1=C(Cl)C=CC(F)=C1Cl
IUPAC Name 3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine
InChI Key KTEIFNKAUNYNJU-UHFFFAOYNA-N
Molecular Formula C21H22Cl2FN5O
2

Crizotinib, Mikromol™

Discover Mikromol - your trusted source for high-quality pharmaceutical reference standards. Supporting accurate, compliant analysis with ISO 17034-accredited materials designed for confidence in every result.

3
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Tocris Bioscience™ Crizotinib
GREENER_CHOICE

CAS: 877399-52-5 Molecular Formula: C21H22Cl2FN5O

CAS 877399-52-5
Molecular Formula C21H22Cl2FN5O
4

Crizotinib, MedChemExpress

MedChemExpress Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition.

ENCOMPASS_PREFERRED
Molecular Weight (g/mol) 450.34
Color Off-White
Physical Form Powder
Chemical Name or Material Crizotinib
Grade Research
SMILES ClC1=C(F)C=CC(Cl)=C1[C@H](OC2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N)C
For Use With (Application) Cancer-Kinase/protease
Percent Purity 97.05%
CAS 877399-52-5
Solubility Information DMSO : 33.33 mg/mL (74.01 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic) (insoluble)
Health Hazard 1 H317∣H319∣H341∣H400
Synonym PF-02341066
Purity Grade Notes Research
Recommended Storage Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula C21H22Cl2FN5O
Formula Weight 450.34